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KMID : 0438219720090010371
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Korea University Medical Journal
1972 Volume.9 No. 1 p.371 ~ p.385
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An Experimental Study on Changes in Water Content and Electrolytes of the Tissue of the Uterus and the Cerebral Cortex in Castrated Rabbits by Long Term Administration of Cortisone
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Abstract
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Author has attempted to clarify the effects of cortisone on electrolytes in the tissue of the uterus and the cerebral cortex of mature female rabbits weighing about 2kg. Determination of electrolytes level of the uterus and the cerebral cortex tissue after administration of cortisone 25mg daily for 2 weeks after castration were undertakan. Levels of Cl, Na, K, Ca, Mg and water content in the organ tissue mentioned in the foregoing were determined and then changes in electrolytes level, comparison of the electrolytes and water contents in these organ tissues were undertaken after a long term administration of cortisone in large doses to castrated rabbits. Flame-photometry was utilized for the determination of Na. and K level, Schales and Schales´ method for Ca and Mg content.
The results obtained are summarized as follows:
1. Serum electrolytes level of female rabbits following castration produced no appreciable changes but a long term administration of cortisone in large doses to castrated female rabbits produced a decrease in Cl, K, Ca and Mg levels.
2. Castration of female rabbits produced an increase in Cl and Ca levels, and decrease in Mg level of the uterine tissue. A long term administration of cortisone in large doses to castrated female rabbits produced a decrease of water content, and an increase in Cl, Na, Ca and Mg levels.
3. Castration produced a marked decrease in water content of the tissue of the cerebral cortex. A long term administration of cortisone in large doses to castrated female rabbits produced an increase in water content, and Ca level whereas a decrease in Cl and K levels.
4 The water content levels of tissue of the uterus and the cerebral cortex were equal to each other in normal, castrated and cortisone administered female rabbits.
5. Cl contents of the tissue of the cerebral cortex of normal, castrated, and large doses of cortisone administered female rabbits showed marked lower level than Cl content of the uterine tissue.
6. Na content of the tissue of the corebral cortex of normal, castrated and large doses of cortisone administered female rabbits showed marked Iower level in comparison with of the uterine time.
7. K content of the tissue of the cerebral cortex of normal and castrated female rabbits showed a marked higher level in comparison with K content of the uterine tissue.
8. Ca content of the tissue of the cerebral cortex of normal female rabbits showed higher level in comparison with that of the uterine tissue. Ca content of the cerebral cortex tissue of large doses of cortisone administered castrated female rabbits showed lower level in comparison with Ca content of the uterine tissue. A
9. Mg content of the tissue of cerebral cortex of normal female rabbits equal to uterine tissue. Mg content of the castrated cerebral cortex tissue of castrated female rabbits showed higher level than that of the uterine tissue. Whereas lower level in cortisone administered female rabbits.
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